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Home > Women's Health > Arimidex

Arimidex

Arimidex 1 mg

Arimidex 1 mg online

Arimidex is a hormonal preparation for breast cancer treatment. It works by lowering estrogen in the body therefore is efficacious against hormone receptor-positive early breast cancer and metastasis. It is usually administered in a dose of 1 mg q24h with the duration of therapy in dependence on the cancer stage and disease progression. No adjustment of drug dosage is needed for elderly patients and women with renal impairment.


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What is Arimidex?

Arimidex is a prescription drug administered for the treatment of breast cancer in postmenstrual women. It is used to treat:
  • early breast cancer in females with hormone receptor-positive tumors and in those who has already undergone surgery.
  • advanced breast cancer with the progression of the disease after tamoxifen therapy.
  • metastatic breast cancer that has spread to other body parts and locally advanced breast cancer that has affected lymph nodes or nearby tissues in females whose disease is hormone receptor unknown or hormone receptor-positive.

What is the mechanism of action of Arimidex?

The active component of Arimidex is anastrozole, a non-steroid inhibitor of an enzyme called aromatase. This enzyme is responsible for the conversion of adrenal androgens into estrone and estradiol in the peripheral tissues. In postmenstrual females, estrogens are mainly synthesized under the action of aromatase.

The drug inhibits aromatase, which leads to reduced conversion of androgens to estrogens and lowers the levels of circulating estrogens in postmenstrual women. All that may slow down the growth of breast tumors that require estrogen to grow in the body. After 14 days of Arimidex therapy, the levels of estradiol are reduced by 80%.

Arimidex does not block the production of female sex hormones by the ovaries; therefore, it is useless in premenopausal women.

What is the proper dosage of Arimidex?

Arimidex should be taken exactly as prescribed by an oncologist. The usual dose is 1 mg taken once per day with or without food. It is recommended to take the drug at the same time every day. The duration of the therapy depends on the severity of the cancer and can last up to 5 years.

What are the possible side effects of Arimidex?

In patients who have a history of ischemic heart disease, Arimidex may cause aggravation of the symptoms of reduced blood flow to the heart.

Other side effects are:
  • skin ulcers, lesion or blisters;
  • allergic reactions;
  • osteoporosis (bone weakness and thinning). Low levels of estrogen cause bones to become weaker and thinner, thus increasing the risk of fractures;
  • increased levels of cholesterol in blood;
  • hot flashes;
  • hypertension;
  • vomiting and nausea.

To know more about Arimidex side effects please see your doctor.

Are there any contraindications?

Arimidex should not be taken by premenopausal women, as it shows no clinical benefit and may cause harm to the fetus if prescribed to a pregnant female. The drug is also contraindicated in patients who have shown hypersensitivity to anastrozole or any other of Arimidex components.

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