Roaccutane is a medication used to treat various dermal diseases and first of all cystic acne. Its active ingredient is Isotretinoin, a retinoic acid naturally found in the body. 10 mg capsules are taken by mouth once or twice a day for 4-8 months. During the first 2-3 weeks of treatment patients may experience worsening of acne, which is the sign that the drug is working.
Roaccutane is a prescription medication for skin conditions treatment and certain skin cancers prevention. Being similar to Vitamin A, this retinoid works by reducing the production of sebum by oil glands, thus reducing bacteria, inflammation and opening blocked pores. Dosage is calculated according to the patient's weight, severity of illness and response to the drug. 20 mg is a usual starting dose, which is increased after a few months of treatment.
Roaccutane is used to treat severe cystic acne, Rosacea, neuroblastoma and leukemia. Each capsule contains 30 mg of Isotretinoin that works by reducing sebaceous glands in size and consequently decreasing sebum production. The drug also improves abnormal keratinization and causes long-lasting anti-acne effect. Pills are usually administered twice a day with food for 15-20 weeks.
What is Roaccutane?
Roaccutane is a monograph drug mainly used to treat cystic acne. As it is sold in many different countries, it carries different names: Accutane, Isotretinoin, Absorbica, Claravis and others. It is classified as a retinoid, which is a class of drugs chemically related to Vitamin A. Retinoids play a very important role in regulating epithelial cell growth. Roaccutane’s mechanism of action is a little complex. Firstly, it reduces the amount of sebum being produced in the body and also shrinks the body’s sebaceous glands. This drug mitigates inflammation in acne, ensures keratinization and prevents comedomes from appearing.
What are the indications for using Roaccutane?
Roaccutane is prescribed for treating the following conditions:
- Cystic acne: a skin disease characterized by papules, nodules, comedomes, seborrhea and pimples appearing on the face or other body parts.
- Harlequin-type ichthyosis - a skin disease that occurs when the keratin layer of the body's skin thickens, causing "scaly" skin.
- Lamellar ichthyosis - a rare skin disorder that also causes scaling of the skin.
What is the dosage of Roaccutane?
Roaccutane is sold in packages with capsules. These capsules come in increments of 10, 20, and 30mg. It is recommended that Roaccutane be taken with food in doses of 0.5mg per kilogram of body weight. In some cases doses of 1mg/kg are also applicable. Treatment is very gradual, and must be maintained for a period of fifteen to twenty weeks.
What are the contraindications for using Roaccutane?
Roaccutane is contraindicated to anyone who is allergic to it or its active substances. It is absolutely prohibited for use by pregnant women, as very serious birth defects may occur, as well as miscarriages and premature births. Roaccutane has been known to interact with tetracyclines, vitamin A-type drugs, and other drugs that cause bone loss. If you take any other prescription drugs, it’s best to consult a doctor before beginning treatment with Roaccutane.
What are the adverse effects of Roaccutane?
Unfortunately, research has uncovered that Roaccutane may cause a number of adverse effects, including anemia, thrombocytopenia, blephartis, conjunctivitis , dermatitis, arthralgia, myalgia, back pain, rash, neutropenia, headache, dry eyes, epistaxis, haematuria, proteinuria, and others. There are also some long-term and permanent effects. For example, studies show that bone growth tends to stop in teenagers being treated with this drug, and other effects such as epiphyseal closure, Crohn’s disease, ulcerative colitis, and decreased night vision have been recorded.
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