This drug is a serotonin 5-HT3 receptor antagonist that is used to treat vomiting and nausea. It comes in the form of regular tablet, a quickly-dissolving tablet, or a liquid solution. It is often given to patients undergoing chemotherapy.
What is Zofran?
Zofran is a drug that is used as an antiemetic. It belongs to the serotonin 5-HT3 receptor antagonist family of drugs and works by preventing the action of serotonin. Serotonin is the substance that causes vomiting and general nausea in the body. Zofran is able to affect the peripheral and central nerves and make the vagus nerve less active that neutralizes vomiting reflex in the medulla oblongata and blocks serotonin. Although it does not affect the motion sickness nausea, Zofran is an excellent drug for treating the nausea and vomiting caused by radiation therapy, cancer chemotherapy, or surgery.
What are the indications for using Zofran?
Zofran is most often prescribed to cancer patients who are undergoing chemotherapy or radiation due to its ability to effectively treat and prevent CINV (chemotherapy-induced nausea and vomiting). Sometimes, it is also given to people after surgery as it can prevent PONV (post-operative nausea and vomiting). Zofran can also be prescribed to pregnant women to treat their morning sickness and hyperemesis gravidarum. It is also prescribed to reduce or completely prevent vomiting in patients suffering from cyclic vomiting syndrome or gastroenteritis.
What is the dosage of Zofran?
The exact dosage of Zofran needs to be determined by the medical practitioner. In the majority of cases, three 8mg tablets are given to patients undergoing a single-day highly emetogenic chemotherapy. They are given 30 minutes before the start of the chemotherapy treatment. For moderately emetogenic cancer chemotherapy, the suggested dose is one 8mg tablet. Children over 12 are given the same dosage as adults, and children under 12 are given one 4mg tablet. Patients, who are undergoing a surgery, are generally prescribed two 8mg Zofran tablets one hour before the start of the surgery.
What are the contraindications for using Zofran?
Zofran should not be given to children under 4 years of age. Also, it should not be taken by individuals who are allergic to ondansetron, or other similar drugs (dolosetron, granisetron, palonosetron, or apomorphine). Zofran may be an inappropriate solution for people with heart or liver disease, congestive heart failure, heart rhythm disorder, electrolyte imbalance, or Long QT syndrome. Also, it should not be taken by those suffering from phenylketonuria.
What are the adverse effects of Zofran?
Some of the mild side effects of Zofran are: headaches, weakness, dizziness, and constipation. There are also several highly unlikely but serious side effects that can occur. They include: vision changes, stomachaches, muscle spasms, chest pain, irregular heartbeat, and fainting. If you experience any of these, get medical help as soon as possible. Allergic reactions to Zofran are relatively rare but can include a rash, dizziness, itching, swelling, or breathing trouble.
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